神经性厌食症是一种严重的饮食障碍

本次大会参会人数达9300位,创endo年会历史新高,共收到摘要约2600份,endo2013希望与会者能从中获得有价值的教育内容和发现新的有启发性的想法以促进临床实践

神经性厌食症

神经性厌食症是一种严重的饮食障碍,虽然男孩、老年人和年轻人都可以患有该病,但其主要患病人群是十几岁的女孩神经性厌食症在少女中的患病率约0.2-1%

这项研究的首席作者,马萨诸塞州总医院和波士顿哈佛医学院的儿科内??分泌专家和儿科副教授madhusmitamisra博士说,这是首次研究发现,雌激素替代疗法可改善神经性厌食症的焦虑倾向,及减轻因体重增加而引起的身体不满意这非常重要,因为神经性厌食症难以治疗,且治疗过程中相关的焦虑症状、饮食态度和对体形的关神经性厌食死亡北京西客站注都可能会降低治疗方案的成功率

受试者包括72名十几岁的确诊为神经性厌食症的女孩研究开始时,所有受试者13至18岁,骨龄至少15岁

研究者随机将受试者分为雌激素或安慰剂治疗18个月最初的72名受试者中,38人接受雌激素治疗和34人接受安慰剂治疗研究开始和结束时,参加者完成评估焦虑、饮食和身体形象态度的问卷37名受试者完成了这项研究,其中20人接受雌激素和17人安慰剂治疗

misra博士说,我们发现降低焦虑倾向以及减少对体重增加的不满可能对减少(神经厌食症)的复发具有重要影响对早期采用雌激素替代疗法治疗雌激素缺乏女孩,这些发现可能影响她们神经性厌食症的治疗

1massachusetts general hospital/harvard medical 神经性厌食证school, boston,ma, 2hospital for sick children, toronto, on, canada,3massachusetts general hospital, boston, ma, 4harriscenter, massachusetts general hospital, boston, ma

【研究摘要】

background:anorexia nervosa (an) is characterized by lowweight, aberrant eating attitudes and behavior (restriction, binge/purgebe神经性厌食症 深圳haviors), body image disturbance and hypogonadism. anxiety is a commonco-morbid condition. estrogen replacement reduces anxiety in ovariectomizedrats, and variations in food intake across the menstrual cycle may also berelated to gonadal hormones. the impact of estrogen replacement on anxiety,eating 男性神经性厌食症attitudes and behavior, and body image has not been reported in patientswith an and merits investigation.

methods: girls with an 13-18 years old and a bone age of atleast 15 years were randomized to physiologic estrogen replacement or placebofor 18 months. the girls received either transdermal estradiol (100 mcg神经性厌食症 深圳 twiceweekly) with cyclic progesterone or placebo for the study duration. in order toinvestigate the effects of estrogen on anxiety symptoms, eating attitudes andbehavior and body image, the spielberger’s state-trait anxiety inventory forchildren (staic), the eating disorders inventory ii question神经性厌食症的原因naire (edi ii), andthe body shape questionnaire (bsq-34) were administered. seventy-two girls withan completed the questionnaires at baseline (38 randomized to estrogen and 34 toplacebo), and 37 at 18 months follow-up (20 randomized to estrogen and 17 toplacebo).

madhusmita misra*1, debra k. katzman2, nara mendesestella3, kar神经性厌食症治疗en klahr miller1, kamryn t. eddy4and anne klibanski1

(本网站所有内容,凡注明来源为“医脉通”,版权均归医脉通所有,欢迎转载,但请务必注明出处,否则将追究法律责任本网注明来源为其他媒体的内容为转载,转载仅作观点分享,版权归原作者所有,如有侵犯版权,请及时联系我们)

impact of estrogen replacement therapy on anxiety symptoms, bodyshape perception and eating attitudes in adolescent girls with anorexianervosa

1/

并发症包括神经性厌食症患者抑郁症,自杀风险升高,骨骼脆弱,从而增加骨折和骨质疏松症风险当女孩的体重下降及雌激素生成减少时,可引起闭经如果不及时治疗,这种疾病可引起死亡不幸的是,厌食症治疗相当困难,复发很常见

-->

conclusions: estrogen replacement led to a reduction intrait anxiety (the tendency to experience anxiety) in adolescent girls with anindependent of weight changes, but did not impact eating attitudes and behavi神经性厌食的症状orsor body shape perception.

objectives: we hypothesized that physiologic estrogenreplacement in adolescents with an would ameliorate anxiety and improve eatingbehavior, without affecting body image.

雌激素替代疗法

在这项研究中,研究人员发现,随着雌激素水平升高,标准化问卷调查焦虑评分下降这种相关性不受体重增加影响此外,进食障碍问卷ii评估显示,如果体重确实增加,雌激素替代疗法似乎可以预防对身体形象和食儿童神精性厌食症医院物的态度恶化

焦虑

endo2013

关键词:

results: girls with an randomized to physiologic estrogenreplacement did not differ from those randomized to placebo for age, bone age,height, weight, bmi, percent ideal body weight and baseline staic, edi ii andbsq-34 scores. additionally, girls who did or did not complete thequestion神经性厌食症后果naires at follow-up did not differ for baseline characteristics.estrogen replacement led to a significant decrease in the staic trait scores(-3.05±5.43 vs. 2.07±6.69, p=0.01), without impacting staic state scores(-1.11±1.83 vs. 0.20±2.06, p=0.64). there was, however, no impact of estrogenreplacement on edi ii男性厌食症 or bsq-34 scores. the groups did not differ for changes inweight or bmi over 18 months, and effects of estrogen replacement on staic traitscores persisted after controlling for changes in weight or bmi (p=0.02 and 0.03respectively). there was an inverse association between change in estradiol andchange in stai神经性厌食病人发病年龄c trait scores over the study duration (r=-0.66, p=0.001).

【导语】第95届美国内分泌学会年会（endo2013）于2013年6月15-18日在美国旧金山隆重举行大会旨在为内分泌领域研究人员提供最前沿的科学知识与技术,包括基础和临床研究医脉通精选部分会议亮点研究以飨读者!

该疾病的特点是身体形象扭曲,患者认为自己超重,或肥胖,甚至当他们的身体质量指数(bmi)远低于正常范围时也是如此随着病情的发展,患者越来越在意通过限制食物和/或增加激烈活动,经常锻炼来减肥有些人甚至通过清除行为(如呕吐,使用泻药)来清除进食的任何食物

endo2013年会上公布的一项新的临床试验发现,雌激素替代疗法可显著减轻患有神经性厌食宝宝神经性厌食症女孩的焦虑症状

白癜风光疗对人体有害吗

转载请注明：http://www.pzegp.com/yszz/476.html